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From Warhammer 40k - Lexicanum
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In Orpheus Salient the Crusade was the most successful initially under the command of [[General]] [[Curas]], bringing sixty systems under its control against secessionist forces and petty rebel empires. However this success was short lived, as [[Tyranid]] [[Hive Fleet]] [[Dagon]] moved into the area and annihilated a large portion of the Salients Crusading forces. Most of the leadership was shattered and at least 50% of troops in the area were lost. At least nine worlds have been overrun by Tyranids in Orpheus Salient.{{Fn|1}}
In Archos Salient, the Crusade is bogged down in bloody fighting against Chaos forces, including warbands of [[Chaos Space Marines]]. The Chaos Marines organized a massive, well-organized counterattack consisting of [[Space Hulk]]s and [[Cruiser]]-class vessels. The Acheros salient fleet, dispersed across the area in twenty sub-groups, were isolated and destroyed while poorly protected troop convoys were hunted down and ravaged. Only the skill of Imperial Navy fleet commanders and Space Marine forges forces prevented a sudden and savage loss of the entire salient, organizing an ordered withdrawal. At least 160,000 troops were lost in the Chaos offensive in six weeks of savage fighting, the majority of which were [[Guardsmen]] who were killed when their transport ships were destroyed.{{Fn|1}}
In Cellebos Salient, a bloody war of attrition is taking place against heretic and secessionist forces. Control for key worlds such as [[Khazant]] and [[Vanity]] has swung back and forth several times.{{Fn|1}}