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Autocannons are usually either mounted on weapon carriages or vehicles because of their great weight.{{Fn|1}}
Due to their high rate of fire and sufficient killing power, they are effective against large infantry formations and light armored vehicles.{{Fn|3}} This , which makes them ideal for use against large [[Tyranid]] organisms and [[Ork]]ish vehicles.{{Fn|4}} They are also useful against heavy infantry such as [[Space Marines]], although their Marines' [[power armour]] has been known to stop autocannon rounds.{{Fn|5}}
Autocannons are used by the [[Imperial Guard]], [[Space Marines]], [[Witch Hunters]], and [[Chaos Space Marines]]. Orks, in particular, enjoy using autocannons because of the prodigious noise and recoil produced by firing them.{{Fn|2}}