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{{Battle3
|Name = Battle of Isstvan III
|Casualties2 = Nearly all Loyalist Marines
|Casualties3 = 8 billion Isstvanians{{Fn|1}}
}}
{{QuoteBox
|quote = '''"Order the guns to fire! Let the galaxy burn!"'''
|source = [[Warmaster]] [[Horus Lupercal]]{{fn|2a}}
|width = 30em
}}
The '''Battle of Isstvan III''' was the start of the [[Horus Heresy]] and was fought between the [[Adeptus Astartes]] loyal to the [[Emperor of Mankind]] and those traitors that swore fealty to [[Imperial Guard Hierarchy#Warmaster|Warmaster]] [[Horus]].{{Fn|1a}}
