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==Known attempts==
*In [[M31]], due to the heavy losses the [[Raven Guard]] [[Legion]] sustained during the [[Isstvan V]] massacre, [[Corax]] asked the Emperor for the technology to replace his numbers and return to combat readiness as quickly as possible. The first group of recruits were successfully turned into marines in a matter of hours. After the resounding success, Corax continued the program, though infiltrators from the Alpha Legion had slipped in with the survivors of the Dropsite Massacre. These Alpha Legionnaires allowed [[Alpharius Omegon|Omegon]] to infiltrate the Raven Guard to steal a copy of the genetech for his own use, as well as sabotage Corax's functional unit. The second and third groups of recruits quickly devolved into [[mutants]]. Despite the initial success and ignorant of the sabotage, Corax deemed the program to be a failure and would continue to create Astartes through the traditional means.{{Fn|2}}{{Fn|3}}
*[[Blackshield Warband]]s made use of Replicaes during the [[Horus Heresy]]. Though it was efficient and could produce vast armies, the process quickly reduced the cloned [[Astartes]] into stumbling drones. These Replicae were also physically mutated, as well as being all but incapable of independent thought and had none of the discipline displayed by the properly trained [[Space Marine Legion]]s. Blackshields also made use of crudely replicated [[Progenoid Gland]]s and those clones that survived the dangerous process of using them, were further mutated into half-mad [[Aberrant (Blackshield)|Aberrants]].{{Fn|9}}
*In [[M41]], in the wake of the disastrous [[Arkio]] Insurrection, [[Apothecary Majoris]] [[Caecus]] of the [[Blood Angels]] proposed using replication. Commander [[Dante]] disapproved, but Caecus continued his research in secret. Caecus believed he had succeeded with the aid of a mysterious [[Magos Biologis]], but his creations, the [[Bloodfiends]], though at first promising, turned into bloodthirsty monsters, manifesting extreme versions of the Blood Angels' geneseed flaws, the [[Black Rage]] and the [[Red Thirst]]. It is uncertain how much of this catastrophe was accident caused by Caecus's incomplete knowledge, and how much was deliberately engineered by the Magos (who turned out to be the traitor [[Fabius Bile]] in disguise).{{Fn|1}}
*{{Endn|7}}: [[Fabius Bile: Clonelord (Novel)]], Chapter 25
*{{Endn|8}}: [[Codex: Leagues of Votann (9th Edition)]], pg. 12
*{{Endn|9}}: [https://archive.ph/t8Rq0 Warhammer Community: Back with the Blackshields – Create your own independent warbands in Warhammer: The Horus Heresy] - [https://assets.warhammer-community.com/eng_09-10_thehorusheresy_legacies_blackshields-19qd4ghgwp-azrdg7jskx.pdf Legacies of the Age of Darkness: Legiones Astartes Blackshields PDF], pg. 10 ''(Saved archive page, dated 9 October 2025, last accessed 9 October 2025, original link: https://www.warhammer-community.com/en-gb/articles/w5my9gyy/back-with-the-blackshields-create-your-own-independent-warbands-in-warhammer-the-horus-heresy/)''
[[Category:Artificial Beings]]
